The Medtronic INFUSE™ Bone Graft (7510400) is an FDA-approved solution designed to support lumbar interbody fusion in patients with degenerative disc disease. This biologic uses bone morphogenetic protein combined with bovine Type I collagen to promote bone growth during a spinal fusion procedure. Clinical studies and clinical trial data support its safety and effectiveness, though healthcare providers must evaluate potential risk, including adverse events, developed antibodies, or use in patients with an active infection. Treatment with the INFUSE Bone Graft and a Medtronic interbody fusion device is recommended specifically for indicated spine surgery, and it is not suitable for women of childbearing potential due to possible impact on fetal development or life-threatening complications.