The Integra DuraSeal® Dural Sealant System (202050) is a synthetic polyethylene glycol (PEG) hydrogel designed to provide a watertight seal for dural repair and cerebrospinal fluid (CSF) leak prevention during cranial and spinal procedures. Its advanced hydrogel technology forms a strong, flexible seal that conforms to tissue surfaces, reinforcing suture or graft closure sites for secure and reliable protection. The DuraSeal® system offers superior tissue adhesion and high bursting strength, proven to withstand critical CSF pressures while maintaining biocompatibility and safety. The blue-tinted hydrogel allows easy visualization during application, ensuring even coverage and accurate placement. Fully reabsorbed within 4–8 weeks, it supports natural dural healing without leaving residue.